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Abstract
This scientific thesis examines the electrophysiological and molecular mechanisms underlying the generation of bioelectrical impulses in the sinoatrial (SA) node, the heart’s primary pacemaker, and their propagation through the atria. It provides a detailed analysis of the interaction between the unstable resting membrane potential of SA nodal pacemaker cells, spontaneous diastolic depolarization (SDD), hyperpolarization-activated I_f (“funny”) currents, and the calcium clock. The dynamics of impulse transmission through specialized conduction pathways to the atria and atrioventricular node are also discussed, along with their diagnostic and therapeutic significance in clinical cardiology.
References
1. DiFrancesco, D. (2010). The role of funny channels in pacemaker activity. Circulation Research, 106(3), 434-446.
2. Lakatta, E. G., & Vinogradova, T. M. (2009). Deciphering the sinoatrial node pacemaker concept: It's a clock shop. Journal of Molecular and Cellular Cardiology, 47(4), 456-466.
3. Mangoni, M. E., & Nargeot, J. (2008). Genesis and regulation of the heart automaticity: physiological and pathological aspects. Physiological Reviews, 88(3), 919-982.
4. Monfredi, O., Maltsev, V. A., & Lakatta, E. G. (2013). Modern concepts of sinoatrial node pacemaker cell automaticity. Journal of Internal Medicine, 273(4), 361-378.
5. Boyett, M. R., Honjo, H., & Kodama, I. (2000). The sinoatrial node, a heterogeneous structure. Progress in Biophysics and Molecular Biology, 74(1-2), 119-156.
6. Irisawa, H., Brown, H. F., & Giles, W. (1993). Cardiac pacemaking in the sinoatrial node. Physiological Reviews, 73(1), 197-227.