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Abstract
This work analyzes the genetic determinacy of bronchial asthma (BA) in childhood. It examines key candidate genes responsible for atopic predisposition and bronchial hyperreactivity. Particular attention is paid to the polymorphism of cytokine and receptor genes that influence the severity of the disease. The findings emphasize the importance of genetic screening for identifying high-risk groups and developing personalized therapy strategies.
References
Pividori, M., et al. (2019). "Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide heterogeneity analysis." The Lancet Respiratory Medicine.
Курбачева О. М., и др. (2021). «Генетические аспекты бронхиальной астмы: от теории к практике». Российский аллергологический журнал.
Ober, C., & Yao, T. C. (2011). "The genetics of asthma and allergic disease: a 21st century perspective." Immunological Reviews.