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Abstract
There is a close correlation between thyroid dysfunction and renal dysfunction. However, unfortunately, thyroid dysfunction can lead to inaccurate measurements of serum creatinine and cystatin C levels. A chronic decrease in cardiac output due to hypothyroidism can reduce renal plasma blood flow (RPF), leading to renal dysfunction. [1].
Results of laboratory studies of kidney and thyroid function before and after treatment showed that the calculated glomerular filtration rate (rGFR) in these patients increased to more than 60 ml/min/1.73 m2 after treatment. Since the calculated glomerular filtration rate (rGFR) after treating thyroid disease can reflect the patient's actual kidney function, such patients can be categorized as patients with "reversible" CKD with hypothyroidism [2].
The authors showed that 13.5% of participants with hypothyroidism had reversible CBD. Considering that 38.5% of CBD cases are defined as pre-existing hypothyroidism, in 35.0% of the population with pre-existing CBD, the disease is reversible, which suggests that some patients with CBD and hypothyroidism can be cured using hormone replacement therapy. Reversible CKD was observed among patients whose KFT values were less than 40 ml/min/1.73 m2 before treatment, which was determined for the G3b stage of CKD. This study clarified the existence of latent CKD in hyperthyroidism and reversible CKD in hypothyroidism.
Hypothyroidism is relatively common among patients with chronic renal disease who do not require chronic dialysis [ 3], and it is known that hypothyroidism can be caused by various mechanisms in chronic renal disease [ 4]. In contrast, primary hypothyroidism is considered a risk factor for both cardiovascular events and nephropathy, and it is known that hypothyroidism, even in its subclinical form (with moderately elevated TSH levels), contributes to kidney dysfunction through mechanisms such as the development of atherosclerosis and direct kidney damage [ 5]. Patients with hypothyroidism also experience a decrease in renal plasma blood flow (RPF).
Thyroid hormones have been reported to exert their effects on thyroid hormone receptors expressed on macrophages, suppressing inflammation and helping to slow the progression of CKD [6]. Furthermore, thyroid hormone replacement therapy may also improve the condition of kidneys damaged by diabetes [7]. These data suggest that thyroid hormone replacement therapy is crucial not only for correcting hormone levels in hypothyroidism but also for protecting the kidneys.
The foregoing served as the basis for the present study.
References
There is a close correlation between thyroid dysfunction and renal dysfunction. However, unfortunately, thyroid dysfunction can lead to inaccurate measurements of serum creatinine and cystatin C levels. A chronic decrease in cardiac output due to hypothyroidism can reduce renal plasma blood flow (RPF), leading to renal dysfunction. [1].
Results of laboratory studies of kidney and thyroid function before and after treatment showed that the calculated glomerular filtration rate (rGFR) in these patients increased to more than 60 ml/min/1.73 m2 after treatment. Since the calculated glomerular filtration rate (rGFR) after treating thyroid disease can reflect the patient's actual kidney function, such patients can be categorized as patients with "reversible" CKD with hypothyroidism [2].
The authors showed that 13.5% of participants with hypothyroidism had reversible CBD. Considering that 38.5% of CBD cases are defined as pre-existing hypothyroidism, in 35.0% of the population with pre-existing CBD, the disease is reversible, which suggests that some patients with CBD and hypothyroidism can be cured using hormone replacement therapy. Reversible CKD was observed among patients whose KFT values were less than 40 ml/min/1.73 m2 before treatment, which was determined for the G3b stage of CKD. This study clarified the existence of latent CKD in hyperthyroidism and reversible CKD in hypothyroidism.
Hypothyroidism is relatively common among patients with chronic renal disease who do not require chronic dialysis [ 3], and it is known that hypothyroidism can be caused by various mechanisms in chronic renal disease [ 4]. In contrast, primary hypothyroidism is considered a risk factor for both cardiovascular events and nephropathy, and it is known that hypothyroidism, even in its subclinical form (with moderately elevated TSH levels), contributes to kidney dysfunction through mechanisms such as the development of atherosclerosis and direct kidney damage [ 5]. Patients with hypothyroidism also experience a decrease in renal plasma blood flow (RPF).
Thyroid hormones have been reported to exert their effects on thyroid hormone receptors expressed on macrophages, suppressing inflammation and helping to slow the progression of CKD [6]. Furthermore, thyroid hormone replacement therapy may also improve the condition of kidneys damaged by diabetes [7]. These data suggest that thyroid hormone replacement therapy is crucial not only for correcting hormone levels in hypothyroidism but also for protecting the kidneys.
The foregoing served as the basis for the present study.