Vol. 1 No. 4 (2026), Articles
Vol. 1 No. 4 (2026)

THE SIGNIFICANCE OF TGF-β1 GENE POLYMORPHISM IN PATIENTS WITH ADVANCED LIVER FIBROSIS

Articles
Published 2026-07-19
J. Ravzatov
Associate Professor, Department of Family Medicine, Andijan State Medical Institute
D. Nabiyeva
Doctor of Medical Sciences, Professor, Head of the Department of Faculty and Hospital Therapy No. 1, Rheumatology and Occupational Pathology, Tashkent State Medical University
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Keywords

liver cirrhosis of various etiologies, fibrogenesis, TGF-β1, CT genotype.

How to Cite

Ravzatov, J., & Nabiyeva, D. (2026). THE SIGNIFICANCE OF TGF-β1 GENE POLYMORPHISM IN PATIENTS WITH ADVANCED LIVER FIBROSIS. Sog‘liqni Saqlashda Yangi Yondashuvlar, 1(4), 10-12. https://doi.org/10.5281/zenodo.21444424
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Abstract

Fibrogenesis plays a decisive role in the development of liver cirrhosis, with transforming growth factor beta 1 (TGF-β1) being one of the key pathogenetic mediators. It is involved in the activation of hepatic stellate cells, increased synthesis of extracellular matrix components, particularly collagen, the formation of fibrotic tissue, and disruption of the architectural structure of the liver parenchyma.

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References

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