Abstract
The article is devoted to the study of the results of complex treatment of sepsis in patients with purulent-necrotic soft tissue diseases by analyzing scientific materials obtained in 56 patients who were treated in the purulent surgery departments of the Andijan State Medical Institute in 2020–2025. A new step-by-step algorithm was used for the diagnosis and comprehensive treatment of sepsis with purulently necrotic soft tissue diseases.
References
1. Abdullayev R.N. «Diabetik oyoq sindromi bo'lgan bemorlarda yiringli -nekrotik asoratlarni davolash o'ziga xosliklari.» Amerika Tibbiyot Fanlari va Farmatsevtika Tadqiqotlari Jurnali (TAJMSPr). 3-jild, 06-son, 2021, 116-121
2. Abdullaev R.N., Abdullaeva M.A./New direction in the treatment of diabetic foot//RE-HEALTH JOURNAL. 2022,№2(14),pp.239-245.
3. Abdullayev R.N. «Diabetik oyoq sindromi bo'lgan bemorlarda yiringli -nekrotik asoratlarni davolash o'ziga xosliklari.» Amerika Tibbiyot Fanlari va Farmatsevtika Tadqiqotlari Jurnali (TAJMSPr). 3-jild, 06-son, 2021, 116-121.
4. Abdullayev R.N./Qandli diabetda oyoqlarning yiringli-nekrotik shikastlanishlarini davolash taktikasi.//Tibbiyotda yangi kun.2022 No6(44),543-549-betlar
5. Aбдуллаев Р.Н., Касымов А.Л., Абдуллаева М.А., Икрамова Ф.Д. /Комплексное лечение сепсиса при гнойно- некротических осложнениях сахарного диабета.// Сборник материалов конференции Ассоциации общих хирургов, приуроченной к юбилею кафедры общей хирургии ЯГМУ. НЕСТИРАЕМЫЕ СКРИЖАЛИ: СЕПСИС ET CETERA Ярославль, 2020.
6. Abdullaev R.N., Abdullaeva M.A., Ziyayeva E`.R., Sobirova M.R./ P a g e Рurulent-necrotic complications of diabetes mellitus a new treatment tactic. // EduVision: Journal of Innovations in Pedagogy and Educational Advancements Volume 01, Issue 11, November 2025 brightmindpublishing.com ISSN (E): 3061-6972ЗР. 319-328. Licensed under CC BY 4.0 a Creative Commons Attribution 4.0 International License.
7. 7.Abdullayev R.N./Qandli diabetda oyoqlarning yiringli-nekrotik shikastlanishlarini davolash taktikasi.//Tibbietda yangi kun.2022 No6(44),543-549-betlar
8. Adem P., Montgomery L., Hussein A. / Bolalarda Staphylococcus aureus va Waterhouse-Friderichsen sindromi sababli sepsis. Ko'krak saratoni. 2006;11:834.
9. Beloborodov V.B./Sepsis klinik tibbiyotning zamonaviy muammosidir. RMJ, 2022. No. 5.342-355. Beloborodov V.B. / Stafilokoklar sababli bakteriemiya va sepsisni davolashda yangi imkoniyatlar .// "Klinik tibbiyot" » 2014г. No3. С. 43-47.
10. Gruver K.P., Beloborodov V.B./ Clinical significance of bacteremia in patients with sepsis. //Clinical microbiology and antibacterial chemotherapy. 2011; 13(1): 90–97.
11. Hotchkiss Richard S., Moldawer Lyle L, Opal Steven M. Sepsis and septic shock. // Nature Reviews Disease Primers. 2016; N 2: 1. P. 1 – 21.
12. Lopatin A.F., Redkin I.V., Samoilenko V.V.et all./ The role of antithrombin in diagnosis and treatment of sepsis ©.// Anesthesiology and resuscitation.2018;(3):19-24 https://doi.org/10.17116/anaesthesiology201803119
13. Makatsaria A.D., Serov V.N., Sukontseva T.A. and others/TIssues of the pathogenesis of coagulopathy in septic shock.// Obstetrics and Gynecology No. 10 / 2019. P. 13-21. DOI: https://dx.doi.org/10.18565/aig.2019.10.13-21.
14. Ramachandran Сirish. /Gram-positive and gram-negative bacterial toxins in sepsis // Virulence. 2013; 5 (1). P. 213–218. https://doi.org/10.4161/ viru.27024/
15. Rybak M.J., Leonard S.N., Rossi K.L., Cheung C.M., Sader H.S., Jones R.N. Characterization of vancomycin-heteroresistant Staphylococcus aureus from the metropolitan area of Detroit, Michigan, over a 22-year period (1986 to 2007). J. Clin. Microbiol. 2008; 46: 2950–4.
16. Ruotsalainen E., Jarvinen A., Koivula I. et al. Levofloxacin does not decrease mortality in Staphylococcus aureus bacteraemia when added to the standard treatment: a prospective and randomized clinical trial of 381 patients. J. Intern. Med. 2006; 259: 179–90.
17. Shapkin Yu.G., Maslyakov V.V., Yu.V.Chalyk Yu.V. Postsplenectomy sepsis. // “Bulletin of Surgery”•2009.No.3. P.68-70.
18. Siuger D. Post-splenectomy sepsis in pediatric pathology.— Chicago: Year Book Med., 1976.—P. 235–311.
19. Takahama M., et al. A pairwise cytokine code explains the organism-wide response to sepsis. // Nat Immunol (2024). DOI: 10.1038/s41590-023-01722-8/.
20. Yiu HH, Graham AL, Stengel RF (2012) Dynamics of a cytokine storm.// PLoSOn,.7:e45027.