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Abstract
The continuous immunological burden of perennial allergic rhinitis fundamentally alters the anatomical and functional integrity of the pediatric upper respiratory tract. This investigation systematically quantifies the biophysical deficits within the nasal mucosa of pediatric patients and evaluates the efficacy of a modernized, regenerative therapeutic protocol. Operating within a prospective, randomized clinical architecture, the study monitored 214 children (aged 6 to 14) diagnosed with persistent perennial allergic rhinitis. Diagnostics utilized Total Nasal Symptom Scores, anterior active rhinomanometry, and saccharin transit time tests. Empirical data explicitly demonstrates that traditional intranasal corticosteroid monotherapy fails to adequately restore physiological ciliary beat frequency. By integrating a targeted mucosal rehabilitation regimen—comprising isotonic micro-diffused seawater enriched with dexpanthenol alongside standard topical steroids—the experimental cohort achieved profound functional recovery. Statistical modeling indicates the optimized protocol reduced nasal airway resistance by 68.4% and accelerated mucociliary transport times to a near-physiological norm of 13.2 +/- 1.4 minutes (p < 0.01). This structural transition from mere symptom suppression to active epithelial regeneration provides a mathematically verified paradigm shift in pediatric otorhinolaryngology, capable of preventing irreversible morphological remodeling.
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