INVESTIGATION OF ACUTE TOXICITY AND SPECIFIC ACTIVITY OF LEVOCARNITINE

Abstract

This study presents the results of investigations on the acute toxicity and specific activity of levocarnitine (“L-CARNITINE” solution for intravenous and intramuscular administration 200 mg/ml, manufactured by S.C. Rompharm Company S.R.L, Romania) in experiments on white mice. Acute toxicity was evaluated by a single intravenous administration of the drug at doses of 500, 1500, and 2500 mg/kg followed by observation of the animals for 14 days. The results demonstrated no mortality among the animals, and the LD50 value was found to be greater than 2500 mg/kg, indicating low toxicity of the preparation. Specific activity was assessed using a swimming endurance test with load under mixed anaerobic-aerobic conditions. The findings showed that levocarnitine increased the physical performance of mice by 49% compared to the control group. The obtained data confirm the safety of the drug as well as its pronounced metabolic and antihypoxic effects.